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Gabriel Byrne plays Father Kiernan, a young Jesuit priest whose degree in chemistry makes him a sort of priest/detective as he investigates weeping Marys and the like around the world. Meanwhile, Frankie (Patricia Arquette), a rave-generation Pittsburgher, is afflicted with the stigmata--holes that appear in her wrists, resembling the wounds of Christ. The young woman's symptoms filter back to the Vatican and Father Kiernan is assigned to the case. The priest is puzzled by Frankie's atheism; usually the stigmata only appear on the devout (hence the age-old controversy of miracles vs. hysteria). Other manifestations appear on Frankie, and...